Two men on a motorbike attacked a bullion van on Spintex Road in Accra. The incident happened during daylight hours on Thursday.
The robbers took an unspecified amount of money from the van. Details about the exact amount stolen have not been released.
The Ghana Police Service has started an investigation into the robbery.
Investigators are gathering information and looking for leads to track down the suspects.
The attack highlights ongoing concerns about security for cash transport in the city.
Police urge anyone with information about the incident to come forward.