Thieves armed with weapons broke into the Golden Bean Hotel. This happened in Kumasi in the early morning hours of Friday.
The robbers took cash and other valuables from the hotel. The exact amount stolen has not been shared.
The Ghana Police Service has started an investigation into the incident. They are looking for the people responsible.
No injuries were reported during the robbery, according to a police statement.
Authorities are asking anyone with information to come forward.
This hotel raid is one of several crimes occurring recently in the Ashanti Region.